Hormesis and age-related declines in performance
Physiological conditioning hormesis, also known as cross tolerance, is the biphasic response associated with stressors, where a lose dose exposure is protective while a high dose is detrimental. Hormesis has a protective effect that leads to an increase in organismal performance and/or fitness. These protective effects can last long into adult life and the mechanisms involved are not fully known. Our lab studies how low-oxygen hormetic treatments can protect against strong oxidizing stressors, like ionizing radiation, and thus boost organismal performance, mating success, and longevity. We are also interest in low irradiation hormesis and its translational potential.
Comparative stress physiology
The main research interests in the lab will always gravitate towards the effects of environmental stress on organismal life history traits. To this end, we always have multiple projects running that involved environmental stress exposure (low or high temperature, dehydration, rehydration, overhydration, UV radiation, gamma radiation, X-ray radiation, anoxia, hypoxia, hyperoxia, infection, and long periods of activity). We study the effects of these stressors (single or multiple exposures) on immediate survival, development, activity, sexual performance, fertility and fecundity, and longevity. We normally avoid model organisms, as their stress physiology responses have been changed by years of lab rearing. We strive to find organisms that are uniquely suited for answering the questions at hand in the appropriate environment.
Current laboratory funding sources: