New Mexico State University

Sophia J. Bailey, Rishi R. Sapkota, Alexandra E. Golliher, Barry Dungan, Marat Talipov, F. Omar Holguin, and William A. Maio Lewis-Acid-Mediated Union of Epoxy-Carvone Diastereomers with Anisole Derivatives: Mechanistic Insight and Application to the Synthesis of Non-natural CBD Analogues Organic Letters 2018

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Thai Phat Truong, Sophia J. Bailey, Alexandra E. Golliher, Erika Y. Monroy, Uttar K. Shrestha, and William A. Maio Exploiting Carvone To Demonstrate Both Stereocontrol and Regiocontrol: 1,2- vs 1,4-Addition of Grignard Reagents and Organocuprates Journal of Chemical Education 2018

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Chao Dong, Diane A. Dickie, William A. Maio, and Thomas A. Manz Synthesis and Characterization of N,N′-Bismesityl Phenanthrene-9,10-diimine and Imine–Nitrone ACS Omega 2018

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Genna, D. T.; Maio, W. A. “There and back again: the synthetic travels of Gary H. Posner.” Tetrahedron 2016

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Hansen, I. A.; Rodriguez, S. D.; Drake, L. L.; Price, D. P.; Blakey, B. N.; Hammond, J. I.; Tsujimoto, H.; Monroy, E. Y.; Maio, W. A.; Romero, A. “The Odorant Co-receptor from the Bed Bug, Cimex lectulatis L.” PLoS ONE. 2014,

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Mehrotra,S.; Duggan, B.; Tello-Aburto, R.; Newar, T.; Gerwick, W.; Murray, T.; Maio, W. “A Detailed Analysis of (–)-Palmyrolide A and Some Synthetic Derivatives as Voltage- Gated Sodium Channel Antagonists.” J. Nat. Prod. 2014, 77, 2553-2560.

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deGruyter, J. N.; Maio, W. A. “The Taumycin A Macrocycle: Asymmetric Total Synthesis and Revision of Relative Stereochemistry.” Org. Lett. 2014, 16, 5196-5199.

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Tello-Aburto, R.; Newar, T. D.; Maio, W. A. “Evolution of a Protecting-Group-Free Total Synthesis: Studies en Route to the Neuroactive Marine Macrolide (–)-Palmyrolide A.” J. Org. Chem. 2012, 77, 6271-6289. PMID: 2272117.

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Tello-Aburto, R.; Johnson, E.M.; Valdez, C.K.; Maio, W.A. “Asymmetric Total Synthesis and Absolute Stereochemistry of the Neuroactive Marine Macrolide Palmyrolide A.” Org. Lett. 2012, 14, 2150.

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Featured in Synfacts: Ley, S. V.; Browne, D. L. Synfacts 2012, 8, 708.

 University of Pennsylvania

Yanran Ai, Mariya V. Kozytska, Yike Zou, Anton S. Khartulyari, William A. Maio, and Amos B. Smith III. “Total Synthesis of the Marine Phosphomacrolide, (−)-Enigmazole A, Exploiting Multicomponent Type I Anion Relay Chemistry (ARC) in Conjunction with a Late-Stage Petasis–Ferrier Union/Rearrangement” J. Org. Chem 2018, 83 (11), 6110–6126.

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Smith, A.B., III; Tong, R.; Kim, W-S.; Maio, W.A. “Anion Relay Chemistry: Access to the Type II ARC Reaction Manifold through a Fundamentally Different Reaction Pathway Exploiting 1-Oxa-2-silacyclopentanes and Related Congeners.” Angew. Chem., Int. Ed. 2011, 50, 8904.

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John Hopkins University

Posner, G.H.; Maio, W.A.; Kalinda, A.S. “Electronically Stabilized Versions  of the Antimalarial Acetal Trioxanes Artemether and Artesunate.” Bioorg. Med. Chem. 2008, 16, 5247.

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Posner, G.H.; Chang, W.; Hess, L.; Woodard, L.; Sinishtaj, S.; Usera, A.; Maio, W.; Rosenthal, A.S.; Kalinda, A.S.; D’Angelo, J.G.; Petersen, K.; Stohler, R.; Chollet, J.; Santo-Thomas, J.; Snyder, C.; Rottman, M.; Wittlin, S.; Brun, R.; Shapiro, T. “Malaria-infected Mice are cured by Oral Administration of New Artemisinin Derivatives.” J. Med. Chem. 2008, 51, 1035.

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Maio, W.A.; Posner, G.H. Sinishtaj, S. “Cyclopentanone Ring Expansion Leading to Functionalized delta-Lactams: Short Synthesis of Simple Sedum Alkaloids.” Org. Lett. 2007, 9, 2673.

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Posner, G.H.; Hatcher, M.A.; Maio, W.A. “New Silicon-Mediated, Sequential Ring Expansions of n-sized 2-Cycloalkenones into Hydroxyolefinic n+m+p Medium-Sized Lactones: Short Synthesis of   (–)-Phoracantholide J.” Org. Lett. 2005, 7, 4301.

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Fordham:

Ciaccio, J.A.; Smrtka, M.; Maio, W.A.; Rucando, D. “Synthesis of β-Hydroxy Nitriles and 1,3-Amino Alcohols from Epoxides Using Acetone Cyanohydrin as a LiCN Precursor.” Tetrahedron Lett. 2004, 45, 7201.

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Patent:

Posner, G.H.; Paik, I.-H.; Borstnik, K.; Chang, W.; Sinishtaj, S.; Usera, A.; Maio, W.A.; D’Angelo, J.G.; Rosenthal, A.S.; Oh, C.-H.; Kalinda, A.S.; Woodard, L.; Hess, L. “Trioxane Dimers Having  Surprisingly High Anticancer and Suprisingly Long-Lasting Antimalarial Activities.” PCT/US2006/044845, Filed 11/17/2006